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Apr 25, 2024
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Catalog 2022-2023 [ARCHIVED CATALOG]
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PHYSIO 235 - Physiological Role of Reactive Oxygen Species in Signal Transduction.
3 Credits
Reactive oxygen species (ROS) are generated in cells through normal cellular metabolism, as well as by exogenous sources. At low levels, ROS can act as signals, whereas at high levels can damage the macromolecules of the cell and result in cell death or aberrant function. Thy phsiological low level of ROS can be required for cellular growth and initiates a different type of cellular signaling than the high levels of ROS that upset the redox balance in the call and cause oxidative stress. This advanced course aims to introduce the students to the chemistry and biochemistry of ROS and redox status of the cell. They will gain an understanding of oxidative stress and the different signaling pathways related to ROS. The course is divided into 4 sections: (1) the chemistry and biochemistry of ROS, (2) signal pathways related to ROS, (3) redox, oxidative stress and cell signaling and (4) the signaling in biological pROSesses and disease. This latter section will integrate the knowledge acquired from sections 1-3 and demonstrate the biological importance of ROS and signal transduction to the physiological workings of the cell.
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